Bioorganic and Medicinal Chemistry Letters p. 1163 - 1168 (1998)
Update date:2022-07-30
Topics:
Levin, Jeremy I.
DiJoseph, John F.
Killar, Loran M.
Sharr, Michele A.
Skotnicki, Jerauld S.
Patel, Dinesh V.
Xiao, Xiao-Yi
Shi, Lihong
Navre, Marc
Campbell, David A.
A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix metalloproteinases collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).
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