The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases

DOI: 10.1016/S0960-894X(98)00186-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1163 - 1168 (1998)

Update date:2022-07-30

Topics:

Authors:

Levin, Jeremy I.

DiJoseph, John F.

Killar, Loran M.

Sharr, Michele A.

Skotnicki, Jerauld S.

Patel, Dinesh V.

Xiao, Xiao-Yi

Shi, Lihong

Navre, Marc

Campbell, David A.

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Article abstract of DOI:10.1016/S0960-894X(98)00186-3

A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix metalloproteinases collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).

Full text of DOI:10.1016/S0960-894X(98)00186-3

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Product name:Trifluoro-methanesulfonic acid 2,2-diphenyl-[1,3]oxathiolan-5-ylmethyl ester

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