The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases

DOI: 10.1016/S0960-894X(98)00186-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1163 - 1168 (1998)

Update date:2022-07-30

Topics:

Authors:

Levin, Jeremy I.

DiJoseph, John F.

Killar, Loran M.

Sharr, Michele A.

Skotnicki, Jerauld S.

Patel, Dinesh V.

Xiao, Xiao-Yi

Shi, Lihong

Navre, Marc

Campbell, David A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00186-3

A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix metalloproteinases collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).

Full text of DOI:10.1016/S0960-894X(98)00186-3

Products guided by the article

Product name:Trifluoro-methanesulfonic acid 2,2-diphenyl-[1,3]oxathiolan-5-ylmethyl ester

Cas No:210034-71-2

R&D Labs maybe for 210034-71-2

ZhangJiaGang YaRui Chemical Co.,Ltd.

Contact:0512-58360968

Address:China JiangSu Province Zhang Jia Gang City YangShe Oriental Plaza Building 10 B307
HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China
Zhejiang Kente Chemical Co.,Ltd.

Contact:86-0576-87651912

Address:No.7, Fengxi West Road, Modern Industrial Zone
Alchemy industrial limited

Contact:+86-18200374913

Address:Hongmei Road, No. 99
ChangZhou Mascotchem. Co.,Ltd.

website:http://www.mascotchem.com

Contact:86-519-85010339

Address:B-802,XingBei Building,391#,Tongjiang Middle Road New District,Changzhou,JS,China

Relevant to this article

Acyl transfer from phosphocholine lipids to melittin

Doi:10.1039/c0cc04677a
(2011)
Reactions of primary and secondary amines with substituted hydroquinones: Nuclear amination, side-chain amination, and indolequinone formation

Doi:10.1021/jo980541v
(1998)
ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia

Doi:10.1021/acschemneuro.6b00181
(2017)
Synthesis and characterization of heterobimetallic complexes with pyridyl selenolato ligands. Crystal structure of [{Pt(C₅H₄N)(SeC₅H₄N)(dppp)}ZnCl₂]

Doi:10.1016/j.jorganchem.2016.12.013
(2017)
Discovery of a potent, orally bioavailable β₃ adrenergic receptor agonist, (R)-N-[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(tri fluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Doi:10.1021/jm000286i
(2000)
Preparation of optically active binaphthylmonophosphines (MOP's) containing various functional groups

Doi:10.1016/S0040-4020(01)89366-2
(1994)

Article Doi