Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists

DOI: 10.1016/S0960-894X(98)00220-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1375 - 1380 (1998)

Update date:2022-08-05

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Authors:

Cimetiere, Bernard

Dubuffet, Thierry

Muller, Olivier

Descombes, Jean-Jacques

Simonet, Serge

Laubie, Michel

Verbeuren, Tony J.

Lavielle, Gilbert

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Article abstract of DOI:10.1016/S0960-894X(98)00220-0

New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886 has been identified as an orally active, highly potent antagonist with a very long duration of action in different species.

Full text of DOI:10.1016/S0960-894X(98)00220-0

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