Bioorganic and Medicinal Chemistry Letters p. 1375 - 1380 (1998)
Update date:2022-08-05
Topics:
Cimetiere, Bernard
Dubuffet, Thierry
Muller, Olivier
Descombes, Jean-Jacques
Simonet, Serge
Laubie, Michel
Verbeuren, Tony J.
Lavielle, Gilbert
New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886 has been identified as an orally active, highly potent antagonist with a very long duration of action in different species.
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Doi:10.1080/00397919808004290
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