Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents

Article abstract of DOI:10.1080/15257779908041570

We have developed a novel class of 2-phosphonate 1,3-dioxolane nucleotide analogues, from which the guanine derivative displayed weak anti- HCMV activity. Further SAR studies led to the identification of both cis and trans guanine derivatives of tetrahydrofuran analogues as potent anti-HCMV agents, both in vitro and in vivo, compared to ganciclovir and HPMPC.

Full text of DOI:10.1080/15257779908041570

This article was downloaded by: [141.214.17.222]
On: 12 November 2014, At: 11:23
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
Design and SAR Study of a Novel Class
of Nucleotide Analogues as Potent Anti-
HCMV Agents
N. Nguyen-ba a , L. Chan a , M. Quimpère a , N. Turcotte a , N. Lee a
, H. Mitchell a & J. Bédard a
a BioChem Therapeutic Inc. , 275 Armand-Frappier, Laval, Québec,
Canada , H7V 4A7
Published online: 04 Oct 2006.
To cite this article: N. Nguyen-ba , L. Chan , M. Quimpère , N. Turcotte , N. Lee , H. Mitchell & J.
Bédard (1999) Design and SAR Study of a Novel Class of Nucleotide Analogues as Potent Anti-HCMV
Agents, Nucleosides and Nucleotides, 18:4-5, 821-827, DOI: 10.1080/15257779908041570
To link to this article: http://dx.doi.org/10.1080/15257779908041570
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or
howsoever caused arising directly or indirectly in connection with, in relation to or arising
out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms &
Conditions of access and use can be found at http://www.tandfonline.com/page/terms-
and-conditions