A PLE-based resolution of cocaine, pseudococaine, and 6-and 7-methoxylated cocaine analogues

DOI: 10.1016/0960-894X(96)00037-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 441 - 444 (1996)

Update date:2022-08-05

Topics:

Authors:

Kozikowski

Simoni Simoni

Baraldi Baraldi

Lampronti

Manfredini

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Article abstract of DOI:10.1016/0960-894X(96)00037-6

The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.

Full text of DOI:10.1016/0960-894X(96)00037-6

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