
Bioorganic and Medicinal Chemistry Letters p. 441 - 444 (1996)
Update date:2022-08-05
Topics:
Kozikowski
Simoni
Baraldi
Lampronti
Manfredini
The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.
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