An efficient synthesis of 2-ethyl-7-chloro-4-methylthieno[4,3,2- e,f][3]benzazepine (SK and F 106686) via bromomethylation of 2-ethyl-5- chlorobenzo[b]thiophene

Article abstract of DOI:10.1080/00397919808004456

The synthesis of 2-ethyl-3-bromoethyl-5-chlorobenzo[b]thiophene (6) is described using a unique phase transfer catalyzed bromoethylation of 2- ethyl-5-chlorobenzo[b]thiophene (5). Compound 6 was converted in six steps and in 55% overall yield to the angio

Full text of DOI:10.1080/00397919808004456

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An Efficient Synthesis
of 2-Ethyl-7-chloro-4-
methylthieno[4,3,2-
e,f][3]benzazepine
(SK&F 106686) via
Bromomethylation
of 2-Ethyl-5-
chlorobenzo[b]thiophene
L. N. Pridgen a , K. Huang a , R. J. Mills a , S.
Shilcrat a & A. Tickner a
a Synthetic Chemistry Department , SmithKline
Beecham Pharmaceuticals , Post Office Box
1539, King of Prussia, PA, 19406-0939
Published online: 22 Aug 2006.
To cite this article: L. N. Pridgen , K. Huang , R. J. Mills , S. Shilcrat & A.
Tickner (1998) An Efficient Synthesis of 2-Ethyl-7-chloro-4-methylthieno[4,3,2-
e,f][3]benzazepine (SK&F 106686) via Bromomethylation of 2-Ethyl-5-
chlorobenzo[b]thiophene, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 28:18, 3479-3489, DOI:
10.1080/00397919808004456
To link to this article: http://dx.doi.org/10.1080/00397919808004456

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