Organic Letters p. 5085 - 5089 (2020)
Update date:2022-09-26
Topics:
Qiao, Jin-Bao
Zhao, Zhen-Zhen
Zhang, Ya-Qian
Yin, Kai
Tian, Zhi-Xiong
Shu, Xing-Zhong
Allylboronates are unique building blocks widely used in organic synthesis, but the construction of cyclic allylboranates remains a challenging subject. We demonstrate here a mild and efficient access to this type of compound through the cross-electrophile coupling of vinyl triflates and α-chloroboronates. The reaction proceeded with a good substrate scope and good functional group compatibility. The ready availability of vinyl triflates from ketones, as well as the rich chemistry of allylboranates, makes our method suitable for the divergent modification of biologically active compounds. Preliminary mechanistic studies revealed that α-chloroboronates were activated via a radical process.
View Morewebsite:http://www.sjzthld.com
Contact:86-311-66699812
Address:NO.600 ZHONGSHAN EAST ROAD SHIJIAZHUANG
Hebei Tianxiang Biological & Pharmaceutical Co., Ltd
Contact:86-0312-6615158
Address:No 42 fazhan street qingyuan county
Contact:--
Address:80G, No.1 Building, Guodu Development Mansion, No. 182 Zhaohui Road, Hangzhou City, Zhejiang Province,China.
LianYunGang Chiral Chemical(CHINA) CO.,LTD
Contact:+86-518-83616958 +86-519-82884848
Address:LianYunGang Chemical Industry Park (JiangSu)
Jinzhou Jiutai Pharmaceutical Co.,Ltd
Contact:+86-0416-5179890
Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
Doi:10.1021/jo010752r
(2002)Doi:10.1039/b211015f
(2003)Doi:10.1016/S0008-6215(98)00161-X
(1998)Doi:10.1021/jo01264a012
(1969)Doi:10.1021/jo981836b
(1998)Doi:10.1080/07328319808004323
(1998)