Nucleosides and Nucleotides p. 2351 - 2365 (1998)
Update date:2022-09-26
Topics:
Khattab, Ahmed F.
Pedersen, Erik B.
2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N4-(1-pyrenylmethyl)-α- cytidine (5) was prepared by reaction of 1-pyrenylmethylamine with an appropriate protected 4-(1,2,4-triazolyl)-α-thymidine derivative 3 which was synthesized from 5-O-DMT protected α-thymidine 1. Aminolysis of 3 afforded 3'-O-acetyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-α-cytidine (8). Benzoylation of 8 and removal of acetyl afforded N4-benzoyl-2-deoxy-5-O- (4,4'-dimethoxytrityl)-5-methyl-α-cytidine (10). The amidites of compounds 5 and 10 were prepared and used in α-oligonucleotide synthesis. DNA three-way junction (TWJ) is stabilized when an α-ODN is used for targeting the dangling flanks of the stem in a DNA hairpin. Further stabilization of the TWJ is observed when 5 is inserted into the α-ODN at the junction region.
View MoreContact:+8618766299236
Address:ROOM808, BUILDING2,NO.230 SHEN ZHEN ROAD, LAOSHAN DISTRICT
Zhengzhou Yuanli Biological Technology Co., Ltd.
Contact:+86-371-67897870/67897895
Address:No. 38, Qingyang Street, Zhengzhou, Henan, China
Beijing Century Richap Chemistry Co.,Ltd
Contact:+86- 010-64455497
Address:Guannan County, Lianyungang City, Jiangsu Province, China
website:http://www.maisonchem.com.cn
Contact:0086-311-83833777
Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
guide(suzhou) fine materials co. ltd
Contact:0512-80972173
Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
Doi:10.1021/jp990857m
(1999)Doi:10.1016/S0040-4020(01)00154-5
(2001)Doi:10.1007/BF00473956
(1992)Doi:10.1021/jo9902190
(1999)Doi:10.1021/jm8010806
(2009)Doi:10.1016/S0040-4020(99)00490-1
(1999)