The 'triamino-analogue' of methyl cholate; A facial amphiphile and scaffold with potential for combinatorial and molecular recognition chemistry

DOI: 10.1016/S0040-4039(98)01254-4

Source and publish data:

Tetrahedron Letters p. 6083 - 6086 (1998)

Update date:2022-08-05

Topics:

Authors:

Broderick, Shay

Davis, Anthony P.

Williams, Robert P.

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Article abstract of DOI:10.1016/S0040-4039(98)01254-4

The triamino steroid 2 is synthesized from cholic acid (1), and found to possess little tendency to aggregate at pH 5 - 6 in aqueous solution. 2 and/or related derivatives are expected to find use in the synthesis of receptors and combinatorial libraries, and as 'contrafacial amphiphiles' for drug delivery across cell membranes.

Full text of DOI:10.1016/S0040-4039(98)01254-4

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