A facile synthesis and some new reactions of N-benzylcarboxamides with essential amino acids

Article abstract of DOI:10.1080/10426509708031609

N-Benzyl-p-chloro and N-Benzyl-2,4-dichlorobenzamide react with hlorosulfonic acid to give the corresponding p-sulfonyl chlorides (1,19), which condensed with nucleophiles to give amino acid derivatives (2-7) and (20-25). Some of the corresponding methyl esters (8-11) were prepared. Hydrazinolysis of these methyl esters yielded the hydrazides (12-15). Coupling reactions of some amino acid derivatives with amino acid methyl ester hydrochloride in THF-Et₃N medium using the dicyclohexylcarbodiimide method furnishes the desired dipeptide methyl esters (16-18, 26-28). Some spectral data are briefly discussed.

Full text of DOI:10.1080/10426509708031609

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Phosphorus, Sulfur, and Silicon and the
Related Elements
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A FACILE SYNTHESIS AND SOME NEW
REACTIONS OF N-BENZYLCARBOXAMIDES
WITH ESSENTIAL AMINO ACIDS
Ragab A. El-sayed a
a Chemistry Department, Faculty of Science , Al-Azhar University , Nasr
City, CAIRO, Egypt
Published online: 24 Sep 2006.
To cite this article: Ragab A. El-sayed (1997) A FACILE SYNTHESIS AND SOME NEW REACTIONS OF N-
BENZYLCARBOXAMIDES WITH ESSENTIAL AMINO ACIDS, Phosphorus, Sulfur, and Silicon and the Related
Elements, 131:1, 207-213, DOI: 10.1080/10426509708031609
To link to this article: http://dx.doi.org/10.1080/10426509708031609
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