Fluorinated linkers for monitoring solid-phase synthesis using gel- phase 19F NMR spectroscopy

Article abstract of DOI:10.1016/S0040-4039(98)01541-X

Three fluorinated linkers which are analogues of linkers commonly used in solid-phase peptide synthesis have been prepared. Using ¹⁹F NMR spectroscopy, the fluorine atom of the linker allowed monitoring of several transformations in the solid-phase synthesis of a peptoid having a coumarin moiety. Especially, attachment of the linker to the solid phase, coupling of the first building block to the linker and cleavage of the product were efficiently monitored and optimised.