(S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid

Base Information

• Chemical Name: (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid
• CAS No.: 213474-81-8
• Molecular Formula: C₂₀H₂₃ClN₂O₅S
• Molecular Weight: 438.932
• Mol file: 213474-81-8.mol

Synonyms:(S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid

Chemical Property of (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid

There total 1 articles about (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + N-(4-chlorosulfonylphenylmethyl)-4-chlorobenzamide (126571-88-8) → (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid (213474-81-8)

Guidance literature:

With water; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1080/10426509708031609

Reference yield: 78.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid (213474-81-8) → ((S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoylamino)-acetic acid methyl ester

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

DOI:10.1080/10426509708031609

Reference yield: 50.0%

methanol (67-56-1) + (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid (213474-81-8) → (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid methyl ester (213474-87-4)

Guidance literature:

With thionyl chloride; for 4h; Ambient temperature;

DOI:10.1080/10426509708031609

upstream raw materials:

L-leucine

N-(4-chlorosulfonylphenylmethyl)-4-chlorobenzamide

Downstream raw materials:

(S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-4-methyl-pentanoic acid methyl ester