Bioorganic and medicinal chemistry letters p. 2157 - 2162 (1998)
Update date:2022-08-05
Topics:
Wolin
Connolly
Afonso
Hey
She
Rivelli
Willams
West Jr.
Sulfonamides derived from 4(5)-(omega-aminoalkyl)-1H-imidazoles containing chain lengths of three- to five-carbons were synthesized. Good to moderate H3 receptor binding affinities were observed for several butyl and pentyl homologs, whereas binding affinities were considerably weaker in the propyl series. Separation of the imidazole ring and the sulfonamide unit by a four- or five-carbon tether afforded potent H3 receptor antagonists.
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Doi:10.1021/ja4122268
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(1968)
