Bioorganic and Medicinal Chemistry Letters p. 2269 - 2272 (1998)
Update date:2022-08-05
Topics: Antifungal Derivatives Antifungal Agents Potent Experimental Sordaricin
Tse, Bruno
Balkovec, James M.
Blazey, Charles M.
Hsu, Ming-Jo
Nielsen, Jennifer
Schmatz, Dennis
Sordarin (1) was converted to 5 and 6, which showed potent antifungal activity against yeast. A series of C1-C9 alkyl side-chain derivatives was prepared, from which it was found that the optimal activity occurred with C5. A comparison of side chains with different unsaturation showed that the cis- alkene was the most active. This result suggested that the folding of the side chains might be crucial for the optimal activity.
View MoreHenan Techway Chemical Co.,Ltd.
website:http://www.techwaychem.com
Contact:+86-371-66380080
Address:No.27 Shunhe Road,
Contact:+86-518-81061113
Address:No. 8 Lingzhou Road, Lianyungang, Jiangsu, China
website:http://www.tbbmed.com
Contact:86--21-50498136
Address:Room 6002, Building 7-1, No.160 Basheng Road,Pudong Area,Shanghai China
Shanghai Goyic Pharmaceutical&Chemical Co,. Ltd
Contact:+86-021-60275964
Address:No. 528 ruiqing road
Jurong Huaheng Natural Biological Products Factory
website:http://www.risebiochem.com
Contact:+86-13921007726
Address:Chuncheng town,Jurong city,Jiangsu province,China
Doi:10.1016/s0020-1693(98)00171-6
(1998)Doi:10.1021/jm200718m
(2011)Doi:10.1016/j.tet.2019.05.014
(2019)Doi:10.1016/S0040-4039(98)01966-2
(1998)Doi:10.1016/S0960-894X(98)00218-2
(1998)Doi:10.1016/S0022-328X(98)00852-3
(1998)