Bioorganic and Medicinal Chemistry Letters p. 2269 - 2272 (1998)
Update date:2022-08-05
Topics: Antifungal Derivatives Antifungal Agents Potent Experimental Sordaricin
Tse, Bruno
Balkovec, James M.
Blazey, Charles M.
Hsu, Ming-Jo
Nielsen, Jennifer
Schmatz, Dennis
Sordarin (1) was converted to 5 and 6, which showed potent antifungal activity against yeast. A series of C1-C9 alkyl side-chain derivatives was prepared, from which it was found that the optimal activity occurred with C5. A comparison of side chains with different unsaturation showed that the cis- alkene was the most active. This result suggested that the folding of the side chains might be crucial for the optimal activity.
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Doi:10.1016/s0020-1693(98)00171-6
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(1998)
