Discovery of MC-02,331, a new cephalosporin exhibiting potent activity against methicillin-resistant staphylococcus aureus

DOI: 10.7164/antibiotics.51.722

Source and publish data:

Journal of Antibiotics p. 722 - 734 (1998)

Update date:2022-08-04

Topics:

Authors:

Hecker, Scott J.

Cho, In-Seop

Glinka, Tomasz W.

Zhang, Zhijia J.

Price, Mary E.

Lee, Ving J.

Christensen, Burton G.

Boggs, Amy

Chamberland, Suzanne

Malouin, Francois

Parr, Thomas R.

Annamalai, Thamil

Blais, Johanne

Bond, Emmett L.

Case, Laura

Chan, Christine

Crase, Jac

Frith, Ria

Griffith, David

Harford, Laurie

Liu, Nancy

Ludwikow, Maria

Mathias, Kristina

Rea, David

Williams, Robert

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.7164/antibiotics.51.722

A systematic approach toward building activity against methicillin-resistant staphylococci into the cephalosporin class of β-lactam antibiotics is described. Initial work focused on finding the optimal linkage between the cephem nucleus and a biphenyl pha

Full text of DOI:10.7164/antibiotics.51.722

Products guided by the article

Product name:(7R)-7-[(Z)-2-(2-N-triphenylmethylaminothiazol-4-yl)-2-(triphenylmethoxyimino)acetamido]-3-[2,4-bis(chloromethyl)phenylthio]-3-cephem-4-carboxylate, 4-methoxybenzyl ester

Cas No:214341-23-8

R&D Labs maybe for 214341-23-8

SHANGHAI RC CHEMICALS CO.,LTD.

website:http://www.rcc.net.cn

Contact:+86-21-50322175

Address:Rm1415 Yinqiao Masion No.58 Jinxin Road Pudong Shanghai China
Water Chemical Co.,LTD

Contact:+86-21-6856-1349 523-87676172

Address:No16 . BinJiang Road . Taixing Economy Developing Area .JiangSu Province . China
Oceachem Group Limited

website:http://www.oceanchem-group.com

Contact:86-536-8596048

Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
Zipont chem(wuhan）Tech co.，Ltd

Contact:+86-27-87587198

Address:wuhan
TIANJIN ZHONGXIN CHEMTECH CO.,LTD.

Contact:86-022-66880623

Address:FINANCIAL STREET WEST BLK 7, #308, NO.52 XINCHENG WEST ROAD, TEDA, TIANJIN, P.R.CHINA

Relevant to this article

An efficient synthesis of optically active metabolites of platelet adhesion inhibitor OPC-29030 by lipase-catalyzed enantioselective transesterification

Doi:10.1016/S0040-4039(99)00946-6
(1999)
An Alternative Access to (+/-)-α-Irones and (+/-)-β-Irone via Acid-Mediated Cyclisation

Doi:10.1002/hlca.19920750312
(1992)
Process development of a potent glucosylceramide synthase inhibitor

Doi:10.1021/op2001222
(2012)
An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines

Doi:10.1021/jo034351i
(2003)
Formation of interim by-products in methanogenic degradation of butyrate

Doi:10.1016/S0043-1354(98)00409-6
(1999)
TOTAL SYNTHESIS OF GLIOTOXIN, DEHYDROGLIOTOXIN AND HYALODENDRIN

Doi:10.1016/S0040-4020(01)97960-8
(1981)

Article Doi