Discovery of MC-02,331, a new cephalosporin exhibiting potent activity against methicillin-resistant staphylococcus aureus

DOI: 10.7164/antibiotics.51.722

Source and publish data:

Journal of Antibiotics p. 722 - 734 (1998)

Update date:2022-08-04

Topics:

Authors:

Hecker, Scott J.

Cho, In-Seop

Glinka, Tomasz W.

Zhang, Zhijia J.

Price, Mary E.

Lee, Ving J.

Christensen, Burton G.

Boggs, Amy

Chamberland, Suzanne

Malouin, Francois

Parr, Thomas R.

Annamalai, Thamil

Blais, Johanne

Bond, Emmett L.

Case, Laura

Chan, Christine

Crase, Jac

Frith, Ria

Griffith, David

Harford, Laurie

Liu, Nancy

Ludwikow, Maria

Mathias, Kristina

Rea, David

Williams, Robert

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Article abstract of DOI:10.7164/antibiotics.51.722

A systematic approach toward building activity against methicillin-resistant staphylococci into the cephalosporin class of β-lactam antibiotics is described. Initial work focused on finding the optimal linkage between the cephem nucleus and a biphenyl pha

Full text of DOI:10.7164/antibiotics.51.722

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