Discovery of MC-02,331, a new cephalosporin exhibiting potent activity against methicillin-resistant staphylococcus aureus

DOI: 10.7164/antibiotics.51.722

Source and publish data:

Journal of Antibiotics p. 722 - 734 (1998)

Update date:2022-08-04

Topics:

Authors:

Hecker, Scott J.

Cho, In-Seop

Glinka, Tomasz W.

Zhang, Zhijia J.

Price, Mary E.

Lee, Ving J.

Christensen, Burton G.

Boggs, Amy

Chamberland, Suzanne

Malouin, Francois

Parr, Thomas R.

Annamalai, Thamil

Blais, Johanne

Bond, Emmett L.

Case, Laura

Chan, Christine

Crase, Jac

Frith, Ria

Griffith, David

Harford, Laurie

Liu, Nancy

Ludwikow, Maria

Mathias, Kristina

Rea, David

Williams, Robert

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.7164/antibiotics.51.722

A systematic approach toward building activity against methicillin-resistant staphylococci into the cephalosporin class of β-lactam antibiotics is described. Initial work focused on finding the optimal linkage between the cephem nucleus and a biphenyl pha

Full text of DOI:10.7164/antibiotics.51.722

Products guided by the article

Product name:(7R)-7-[(Z)-2-(2-N-triphenylmethylaminothiazol-4-yl)-2-(triphenylmethoxyimino)acetamido]-3-[2,4-bis(chloromethyl)phenylthio]-3-cephem-4-carboxylate, 4-methoxybenzyl ester

Cas No:214341-23-8

R&D Labs maybe for 214341-23-8

Chengdu Cogon Bio-tech Co., Ltd.

Contact:86-28-85171192

Address:NO.52.YongFeng Rd. Chengdu,610041,P.R.China.
shanghai hekang chemical co.ltd

Contact:021-54173790

Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China
Shaanxi HuaTai Bio-fine chemical company Ltd

Contact:86-029-87862197

Address:No. 5, 3rd Floor, 29 Yanta North Road, Beilin Dist.
SHANDONG QINGYUNCHANGXIN CHEMICAL SCIENCE-TECH CO.,LTD

Contact:86-21-60560171

Address:1689Donghuan Rade,Qingyun County, Dezhou City, Shandong,China
Zhuzhou Farshine Chemical Industry Co., Ltd

Contact:0086-731-28482786

Address:No. 1,Shui Xian Road, He Tang Dictrict,Hunan-412000,China

Relevant to this article

An efficient synthesis of optically active metabolites of platelet adhesion inhibitor OPC-29030 by lipase-catalyzed enantioselective transesterification

Doi:10.1016/S0040-4039(99)00946-6
(1999)
An Alternative Access to (+/-)-α-Irones and (+/-)-β-Irone via Acid-Mediated Cyclisation

Doi:10.1002/hlca.19920750312
(1992)
Process development of a potent glucosylceramide synthase inhibitor

Doi:10.1021/op2001222
(2012)
An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines

Doi:10.1021/jo034351i
(2003)
Formation of interim by-products in methanogenic degradation of butyrate

Doi:10.1016/S0043-1354(98)00409-6
(1999)
TOTAL SYNTHESIS OF GLIOTOXIN, DEHYDROGLIOTOXIN AND HYALODENDRIN

Doi:10.1016/S0040-4020(01)97960-8
(1981)

Article Doi