A simple synthesis of 2',5'-disubstituted-spiro [dihydroacridine 9(10H), 4'-thiazolines] by the reaction of corresponding 3-(acridin-9-yl)-thioureas with methyl bromoacetate and bromoacetonitrile

Article abstract of DOI:10.1080/00397919809458697

A convenient method has been devised for the preparation of the spirodihydro-acridinethiazolines 5a-j by the treatment of thioureas 3a-e with methyl bromoacetate and bromoacetonitrile via non-isolable isothioureas 4a-j and their subsequent cyclization wit

Full text of DOI:10.1080/00397919809458697

This article was downloaded by: [The University Of Melbourne Libraries]
On: 14 September 2014, At: 10:18
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number:
1072954 Registered office: Mortimer House, 37-41 Mortimer Street,
London W1T 3JH, UK
Synthetic Communications:
An International Journal
for Rapid Communication of
Synthetic Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
A Simple Synthesis of
2′,5′-Disubstituted-Spiro
[Dihydroacridine 9(10H),
4′-Thiazolines] by the
Reaction of Corresponding
3-(Acridin-9-Yl)-Thioureas
with Methyl Bromoacetate
and Bromoacetonitrile
Juraj Bernát a , Igor Chomča a , Pavol Kristian a
& Gundula Voss b
a Department of Organic Chemistry , P.J. Šafarik
University , SK-041 67, Košice, Slovakia
b Department of Organic Chemistry , Bayreuth
University , D-954 47, Bayreuth, Germany
Published online: 11 Mar 2009.
To cite this article: Juraj Bernát , Igor Chomča , Pavol Kristian & Gundula Voss
(1998) A Simple Synthesis of 2′,5′-Disubstituted-Spiro [Dihydroacridine 9(10H),
4′-Thiazolines] by the Reaction of Corresponding 3-(Acridin-9-Yl)-Thioureas with
Methyl Bromoacetate and Bromoacetonitrile, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry,
28:22, 4171-4178, DOI: 10.1080/00397919809458697
To link to this article: http://dx.doi.org/10.1080/00397919809458697

PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all
the information (the “Content”) contained in the publications on our
platform. However, Taylor & Francis, our agents, and our licensors
make no representations or warranties whatsoever as to the accuracy,
completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of
the authors, and are not the views of or endorsed by Taylor & Francis.
The accuracy of the Content should not be relied upon and should be
independently verified with primary sources of information. Taylor and
Francis shall not be liable for any losses, actions, claims, proceedings,
demands, costs, expenses, damages, and other liabilities whatsoever
or howsoever caused arising directly or indirectly in connection with, in
relation to or arising out of the use of the Content.
This article may be used for research, teaching, and private study
purposes. Any substantial or systematic reproduction, redistribution,
reselling, loan, sub-licensing, systematic supply, or distribution in any
form to anyone is expressly forbidden. Terms & Conditions of access
and use can be found at http://www.tandfonline.com/page/terms-and-
conditions