Synthesis and binding property of an oligonucleotide containing tetrafluorophenoxazine

Article abstract of DOI:10.1016/S0040-4039(98)01932-7

A tricyclic pyrimidine nucleoside analog, termed tetrafluorophenoxazine, has been synthesized and incorporated into an oligonucleotide. Tm analyses demonstrate that this analog is capable of enhanced recognition of both a complementary adenine and guanine within a DNA helix.