European Journal of Medicinal Chemistry p. 715 - 724 (1998)
Update date:2022-08-02
Topics:
Nicolaides, Demetrios N.
Fylaktakidou, Konstantina C.
Litinas, Konstantinos E.
Hadjipavlou-Litina, Dimitra
A series of novel coumarin-4-carboxamidoximes 6a-g and 3-(coumarin-4- yl)-1,2,4-oxadiazoles 9a-e were synthesized from coumarin-4-carboxaldehyde 1 via the intermediate coumarin-4-nitriloxide 4. These coumarin derivatives were isolated and characterized, and evaluated for their ability to inhibit trypsin, glucuronidase, and soybean lipoxygenase. The compounds were also tested for antioxidant activity, and as antiinflammatory agents in the rat carrageenin paw edema assay.
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