Synthesis of enantiomerically pure 3-amino-1,2-diols by reductive amination of racemic 2,3-dialkoxyketones

Article abstract of DOI:10.1016/S0040-4039(98)01856-5

The reductive amination of racemic 2,3-dialkoxyketones by tetrabutylammonium triacetoxyborohydride in the presence of (R) or (S)-α- methylbenzylamine allows the stereocontrolled access to 3-amino-1,2-diols in high enantiomerical purity via a partial dynamic resolution.