A synthetic route to a novel type of conformationally constrained N-aryloxazolidinones

Article abstract of DOI:10.1016/j.bmcl.2005.03.071

The synthesis of N-aryloxazolidinone 1, a conformationally constrained analog of linezolid embodying a tricyclic pyrrolo[1,2-a][4,1]benzoxazepine moiety as the N-aryl substituent, is reported. The synthetic route involves the successive construction of th