Bioorganic and Medicinal Chemistry Letters p. 2813 - 2816 (1998)
Update date:2022-08-03
Topics:
Fu, Jian-Min
Castelhano, Arlindo L.
A novel pyridone-based tyrosine analog, 6, has been designed to mimic the binding interaction of SH2 domains with phosphotyrosine (pTyr) containing peptides. Synthesis of 6 features a key Pd catalyzed coupling of β- iodoalanine with phosphonomethyl 4-pyridone triflate.
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Doi:10.1007/BF00812333
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