Design and synthesis of a pyridone-based phosphotyrosine mimetic

DOI: 10.1016/S0960-894X(98)00503-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2813 - 2816 (1998)

Update date:2022-08-03

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Authors:

Fu, Jian-Min

Castelhano, Arlindo L.

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Article abstract of DOI:10.1016/S0960-894X(98)00503-4

A novel pyridone-based tyrosine analog, 6, has been designed to mimic the binding interaction of SH2 domains with phosphotyrosine (pTyr) containing peptides. Synthesis of 6 features a key Pd catalyzed coupling of β- iodoalanine with phosphonomethyl 4-pyridone triflate.

Full text of DOI:10.1016/S0960-894X(98)00503-4

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