Cyclisation of meta-phenylene-bis-alanine derivatives

Article abstract of DOI:10.1039/a805350b

The cyclisation of a meta-phenylene-bis-alanine derivative with several different spacer moieties was investigated. A large difference in the ease of cyclisation was observed depending on which path of cyclisation was chosen. NMR studies indicate that the closed-loop molecules adopt folded conformations with the loop directly above the aromatic ring plane.