4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

DOI: 10.1016/S0960-894X(99)00132-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1057 - 1062 (1999)

Update date:2022-07-29

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Authors:

Cocuzza, Anthony J.

Hobbs, Frank W.

Arnold, Charles R.

Chidester, Dennis R.

Yarem, Jerry A.

Culp, Steven

Fitzgerald, Lawrence

Gilligan, Paul J.

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Article abstract of DOI:10.1016/S0960-894X(99)00132-8

A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.

Full text of DOI:10.1016/S0960-894X(99)00132-8

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