4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

DOI: 10.1016/S0960-894X(99)00132-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1057 - 1062 (1999)

Update date:2022-07-29

Topics:

Authors:

Cocuzza, Anthony J.

Hobbs, Frank W.

Arnold, Charles R.

Chidester, Dennis R.

Yarem, Jerry A.

Culp, Steven

Fitzgerald, Lawrence

Gilligan, Paul J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00132-8

A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.

Full text of DOI:10.1016/S0960-894X(99)00132-8

Products guided by the article

Product name:2-chloro-4-methyl-6-(2-trifluoromethyl-phenyl)-pyrimidine

Cas No:219840-86-5

R&D Labs maybe for 219840-86-5

Taizhou KEDE Chemical.Co.,Ltd.

Contact:86-576-84613060

Address:Jiangkou Chemical Zoon
SPRING CHEMICAL INDUSTRY CO.,LTD

Contact:86-187-66672125

Address:linchi industry park.zouping
Synasia Inc

Contact:17316303296

Address:240 Amboy Ave
Beijing eternalchem Co,. Ltd

Contact:+86-10-59484199

Address:No.58-A1026 Liangguan Street
Hangzhou Share Chemical Co., Ltd(expird)

Contact:+86-57187093700

Address:Hang Xing Road

Relevant to this article

DIECKMANN-SHAPIRO CONDENSATION OF SUBSTITUTED PHTHALIDES WITH p-DIMETHYLAMINOBENZALDEHYDE

Doi:10.1007/BF00954613
(1986)
Asymmetric synthesis of N-protected syn and anti (E)-3-amino-2-hydroxy- 4-hexenoate: A practical method for the C-α epimerization of anti β-amino- α-hydroxy acids

Doi:10.1016/S0040-4020(98)01051-5
(1999)
A facile preparation of buspirone N-oxide using Davis' reagent

Doi:10.1080/00304949609355915
(1996)
Phosphenium complexes 30. Supermesitylphosphenium complexes of molybdenum and tungsten: Synthesis and exchange reactions involving the P-H bond

Doi:10.1016/S0022-328X(98)00947-4
(1999)
Doi:10.1002/jps.2600500723
(1961)
Transition metal complexes with sulfur ligands, 135 [(+)] - Electron- rich Fe and Ru complexes with the new trisamine dithiolate ligand 'N₃H₃S₂'-H₂-bis(2-mercaptophenylamino)diethylamine]

Doi:10.1002/(sici)1099-0682(19990202)1999:2<341::aid-ejic341>3.0.co;2-v
(1999)

Article Doi