4-Nitrosophenetole-Glutathione S-Conjugates
Chem. Res. Toxicol., Vol. 11, No. 12, 1998 1421
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Con clu sion s. In summary, all NOPt/GSH metabo-
lites elucidated hitherto can be explained starting from
a central sulfenamide cation that enables multiple reac-
tion pathways. The product pattern reveals striking
similarity with other arylnitrenium ions accused as
ultimate carcinogens. Hence, the DNA reactivity of
sulfenamide cations may be of concern as well. Moreover,
formation of quinoid metabolites is expected to contribute
to the toxic potential of nitrosoarenes reacting with thiols.
Ack n ow led gm en t. The financial support of the DFG
(Deutsche Forschungsgemeinschaft; AZ:Ga 495/2-1) is
gratefully acknowledged.
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