Bioorganic and Medicinal Chemistry Letters p. 3143 - 3148 (1998)
Update date:2022-08-03
Topics:
Fevig, John M.
Cacciola, Joseph
Alexander, Richard S.
Knabb, Robert M.
Lam, Gilbert N.
Wong, Pancras C.
Wexler, Ruth R.
The serine protease factor Xa is a critical enzyme in the blood coagulation cascade. Recently, the inhibition of factor Xa has begun to emerge as an attractive strategy for the discovery of novel antithrombotic agents. Here we describe a series of meta-amidino-N,N-disubstituted anilines as structurally simple and very potent inhibitors of factor Xa.
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