Bioorganic and Medicinal Chemistry Letters p. 145 - 150 (1999)
Update date:2022-08-03
Topics:
Zembower, David E.
Zhang, Heping
Lineswala, Jayana P.
Kuffel, Mary J.
Aytes, Shelley A.
Ames, Matthew M.
All four 'symmetrical' regioisomers of ED-110, an indolocarbazole derivative having potent activity against human topoisomerase I (Topo I) were synthesized. The isomer containing hydroxyl groups in the 3- and 9-positions was approximately ten-fold more active against Topo I, and 5- to 35-fold more active against human solid tumor cell lines in vitro, relative to ED-110.
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