Bioorganic and Medicinal Chemistry Letters p. 145 - 150 (1999)
Update date:2022-08-03
Topics:
Zembower, David E.
Zhang, Heping
Lineswala, Jayana P.
Kuffel, Mary J.
Aytes, Shelley A.
Ames, Matthew M.
All four 'symmetrical' regioisomers of ED-110, an indolocarbazole derivative having potent activity against human topoisomerase I (Topo I) were synthesized. The isomer containing hydroxyl groups in the 3- and 9-positions was approximately ten-fold more active against Topo I, and 5- to 35-fold more active against human solid tumor cell lines in vitro, relative to ED-110.
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Doi:10.1021/jo9714324
(1997)Doi:10.1016/S0040-4020(01)00044-8
(2001)Doi:10.1021/ol502436n
(2014)Doi:10.1016/S0040-4039(01)87511-0
(1969)Doi:10.1002/(SICI)1521-3765(19990301)5:3<951::AID-CHEM951>3.0.CO;2-G
(1999)Doi:10.1021/jm020881f
(2002)
