Indolocarbazole poisons of human topoisomerase I: Regioisomeric analogues of ED-110

DOI: 10.1016/S0960-894X(98)00710-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 145 - 150 (1999)

Update date:2022-08-03

Topics:

Authors:

Zembower, David E.

Zhang, Heping

Lineswala, Jayana P.

Kuffel, Mary J.

Aytes, Shelley A.

Ames, Matthew M.

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Article abstract of DOI:10.1016/S0960-894X(98)00710-0

All four 'symmetrical' regioisomers of ED-110, an indolocarbazole derivative having potent activity against human topoisomerase I (Topo I) were synthesized. The isomer containing hydroxyl groups in the 3- and 9-positions was approximately ten-fold more active against Topo I, and 5- to 35-fold more active against human solid tumor cell lines in vitro, relative to ED-110.

Full text of DOI:10.1016/S0960-894X(98)00710-0

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