Nucleophilic perfluoroalkylation of nitrones

DOI: 10.1016/S0040-4039(98)80010-5

Source and publish data:

Tetrahedron Letters p. 25 - 28 (1999)

Update date:2022-08-03

Topics:

Authors:

Nelson, Derek W.

Easley, Regina A.

Pintea, Beniamin N. V.

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Article abstract of DOI:10.1016/S0040-4039(98)80010-5

New methods for perfluoroalkylation of carbon-nitrogen double bonds have been developed. Addition of (trifluoromethyl)trimethylsilane (TMSCF₃) to α,N-diarylnitrones produced α series of α-(trifluoromethyl)-N hydroxyl amines protected as their O-trimethylsilyl derivatives. An alternate procedure using pentafluoroethyllithium (F₅C₂L₁) and chlorotrimethylsilane (TMSCI) afforded O-trimethylsilyl-α-(pentafluoroethyl)-N-hydroxyl amines.

Full text of DOI:10.1016/S0040-4039(98)80010-5

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