Improvement of the diastereoselectivity of the cobalt-mediated [2+2+2] cycloaddition of substituted linear enediynes

Article abstract of DOI:10.1016/S0040-4039(98)02483-6

The level of the diastereoselectivity of the cobalt-mediated [2+2+2] cyclization of linear enediynes was improved compared to that reported in the literature by substituting the triple or the double bond with ester, phosphine oxide or sulfoxide groups.