Synthesis and anticonvulsant activity of novel and potent 2,3- benzodiazepine AMPA/kainate receptor antagonists

DOI: 10.1021/jm991086d

Source and publish data:

Journal of Medicinal Chemistry p. 4414 - 4421 (1999)

Update date:2022-08-03

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Authors:

Grasso, Silvana

De Sarro, Giovambattista

De Sarro, Angela

Micale, Nicola

Zappala, Maria

Puia, Giulia

Baraldi, Mario

De Micheli, Carlo

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Article abstract of DOI:10.1021/jm991086d

We have previously shown that 1-aryl-3,5-dihydro-7,8-methylenedioxy-4H- 2,3-benzodiazepin-4-ones (3) possess marked anticonvulsant properties and antagonize seizures induced by 2-amino-3-(3-hydroxy-5-methylisoxazol-4- yl)propionic acid (AMPA) in analogy t

Full text of DOI:10.1021/jm991086d

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