Identification of a hexasaccharide sequence able to inhibit thrombin and suitable for 'polymerisation'

Article abstract of DOI:10.1016/S0008-6215(99)00067-1

Three hexasaccharides, having from low to very high affinity for antithrombin, were synthesised from disaccharide building block precursors. One of them, methyl(sodium 2,3-di-O-methyl-4-O-sodium sulfonato-α-L-idopyranosyluronate)-(1→4)-[(2,3,6-tri-O-sodium sulfonato-α-D-glucopyranosyl)-(1→4)-(sodium 2,3-di-O-methyl-α-L-idopyranosyluronate)-(1→4)]₂-2,3,6-tri-O-sodium sulfonato-α-D-glucopyranoside, obtainable from a single disaccharide building block precursor, constitutes a good starting point for obtaining simple oligosaccharidic heparin mimetics able to inhibit the two coagulation factors thrombin and Factor Xa. Copyright (C) 1999 Elsevier Science Ltd.