Journal of Heterocyclic Chemistry p. 65 - 73 (1999)
Update date:2022-08-04
Topics:
Dantanarayana, Anura P.
DuPre, Brian
May, Jesse A.
Lynch, Vincent M.
3-(Methoxymethoxymethyl)-2-thiophenesulfonamides and 3-hydroxymethyl-N- methoxymethyl-2-thiophenesulfonamides have been shown to undergo cyclization when treated under anhydrous acidic conditions to provide the novel 2,3- dihydro-5H-thieno[2,3-e]-4,1,2-oxathiazepine ring system. Incorporation of a primary sulfonamide group into position seven of the molecule provided compounds which inhibit human carbonic anhydrase II.
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