Studies toward the synthesis of natural and unnatural dienediynes 1. Approaches to a functionalised bicyclic ring system

Article abstract of DOI:10.1016/S0040-4020(99)00045-9

The synthesis of a functionalised bicyclic ring system related to the naturally occurring dienediynes, NCS and Kedarcidin Chromophores is presented. Key steps involve: conjugate addition of an enediyne to a functionalized enone and intramolecular boron mediated aldol reaction.