
Journal of the Chinese Chemical Society p. 941 - 946 (1999)
Update date:2022-08-03
Topics:
Lan, Jiong
Liu, Zuosheng
Li, Yulin
Cen, Wen
Xing, Yacheng
Preverecynarmin, isolated from a pennatulacean coral, has been synthesized from E,E-famesol. The key steps are alkylation of the cyanohydrin trimethylsilyl ether 5 with the halide 6, the regioselective epoxidation of the siloxyl ether 9, and the intramolecular macrocyclization of the siloxyl ether 12 induced by Ti(0).
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