Tetrahedron Letters p. 4137 - 4140 (1997)
Update date:2022-08-05
Topics: Experimental Route
Bermudez
Del Campo
Sinisterra
Llama
Amino-2-propanol structures can be obtained by addition to dibenzyl acetals of in situ generated dihalocarbenes using LTV (Low Valent Titanium). This methodology can be used to obtain adrenergic β-blockers with amino-2-propanol structure. Tetrahalomethane are the best dihalocarbene precursors. The yields obtained using halofluromethanes can be increased by addition of carbontetrachloride. A process that can imply halogen transfer may be proposed.
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Doi:10.1016/0022-328X(89)88037-4
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