Non-peptide αvβ3 antagonists. Part 7: 3-Substituted tetrahydro-[1,8]naphthyridine derivatives

DOI: 10.1016/j.bmcl.2003.11.036

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1049 - 1052 (2004)

Update date:2022-08-05

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Authors:

Wang, Jiabing

Breslin, Michael J.

Coleman, Paul J.

Duggan, Mark E.

Hunt, Cecilia A.

Hutchinson, John H.

Leu, Chih-Tai

Rodan, Sevgi B.

Rodan, Gideon A.

Duong, Le T.

Hartman, George D.

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Article abstract of DOI:10.1016/j.bmcl.2003.11.036

A series of 3-substituted tetrahydro-[1,8]naphthyridine containing α_vβ₃ antagonists was prepared. A comparison of their in vitro IC₅₀ values to the electron properties of the 3-substituents revealed a good linear Hammett c

Full text of DOI:10.1016/j.bmcl.2003.11.036

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