Tetrahedron p. 7251 - 7270 (1999)
Update date:2022-07-30
Topics:
Vieira de Almeida, Mauro
Dubreuil, Didier
Cleophax, Jeannine
Verre-Sebrie, Catherine
Pipelier, Muriel
Prestat, Guillaume
Vass, Georges
Gero, Stephane D.
The synthesis of opticaly pure deoxy-myo-inositol mono, bis and trisphosphate analogues is described from 4-O-benzyl-2,3-di-O- cyclohexylidene-6-deoxy-myo-inositol and corresponding 1,5 epimer chiro- inositol. These precursors, which derive from galactose, are used to accede to a variety of cyclitol intermediates employing protection/deprotection sequence. The phosphorylation procedure was performed to produce free and original substituted phosphate derivatives aimed to be incorporated through the lipidic cell membrane for in vivo evaluation.
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