Novel quinazolone derivatives as antitumor agents

Article abstract of DOI:10.1080/10426509808029666

A novel series of quinazolones bearing 2-benzoylmethylthio 3, 2-benzoylmethylsulfonyl 4, 1,3,4-oxadiazine 6, 1,2,4-triazine 7, ethyl ester 8, pyrazolidine-3,5-dione 9, semicarbazide 10, 1,2,4,5-tetrazine-3-one 11, pyridazine-3,5-dione 12, 13, hydrazonoacetic acid 14, pyridazine-3,6-dione 16, pyrazole 17, 1,2,4-triazine-5-one 18, triazole 19 and thiosemicarbazide 20 have been synthesized. Their structures have been confirmed on the basis of elemental analyses and (IR, ¹H-NMR & Mass) spectral data. Preliminary testing for the in vitro antitumor activity of compounds 1, 3, 4, and 15-20 against Ehrlich Ascites Carcinoma cells was carried out. The most active compounds are those of chloroacetylhydrazine derivative 15, pyridazine derivative 16, sulfonyl derivative 4, and triazine derivative 18, respectively.

Full text of DOI:10.1080/10426509808029666

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Phosphorus, Sulfur, and Silicon
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NOVEL QUINAZOLONE
DERIVATIVES AS ANTITUMOR
AGENTS
M. M. Ghorab a , S. G. Abdel-hamide b & S. M. El-
sayed c
a Department of Drug Radiation Research, National
Centre for Radiation Research and Technology,
(NCRRT), P.O. Box 29, Nasr City, Cairo, Egypt
b Pharmaceutical Chemistry Department, Faculty of
Farmacy, Al-Azhar University, Nasr City, Cairo, Egypt
c Biology Department, National Centre for Radiation
Research and Technology, Cairo, Egypt
Version of record first published: 24 Sep 2006
To cite this article: M. M. Ghorab, S. G. Abdel-hamide & S. M. El-sayed (1998): NOVEL
QUINAZOLONE DERIVATIVES AS ANTITUMOR AGENTS, Phosphorus, Sulfur, and Silicon
and the Related Elements, 142:1, 57-68
To link to this article: http://dx.doi.org/10.1080/10426509808029666
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