N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5- lipoxygenase

DOI: 10.1016/S0960-894X(99)00117-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 979 - 984 (1999)

Update date:2022-08-03

Topics:

Authors:

Connolly, Peter J.

Wetter, Steven K.

Beers, Kimberly N.

Hamel, Stephanie C.

Chen, Robert H. K.

Wachter, Michael P.

Ansell, Justin

Singer, Monica M.

Steber, Michele

Ritchie, David M.

Argentieri, Dennis C.

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Article abstract of DOI:10.1016/S0960-894X(99)00117-1

Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (1a and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay.

Full text of DOI:10.1016/S0960-894X(99)00117-1

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