Bioorganic and Medicinal Chemistry Letters p. 979 - 984 (1999)
Update date:2022-08-03
Topics:
Connolly, Peter J.
Wetter, Steven K.
Beers, Kimberly N.
Hamel, Stephanie C.
Chen, Robert H. K.
Wachter, Michael P.
Ansell, Justin
Singer, Monica M.
Steber, Michele
Ritchie, David M.
Argentieri, Dennis C.
Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (1a and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay.
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(1999)
