Chemical and Pharmaceutical Bulletin p. 1193 - 1195 (1999)
Update date:2022-08-04
Topics:
Okada, Yoshio
Fukumizu, Atsuko
Takahashi, Motohiro
Yokoi, Toshio
Tsuda, Yuko
Bryant, Sharon D.
Lazarus, Lawrence H.
Cyclization of dipeptidyl chloromethyl ketones gave 6-(4-aminobutyl)-3- carboxyethyl-5-methyl-2(1H)-pyrazinone, 3-(4-aminobutyl)-6-carboxyethyl-5- methyl-2(1H)-pyrazinone, and 3,6-bis(4-aminobutyl)-5-methyl-2(1H)-pyrazinone, which were inserted into the enkephalin sequence to give opioid mimetics. Thus, it was confirmed that a pyrazinone ring can be easily inserted into a peptide sequence in order to evaluate structural components required for biologically active peptides.
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