Chemical and Pharmaceutical Bulletin p. 1193 - 1195 (1999)
Update date:2022-08-04
Topics:
Okada, Yoshio
Fukumizu, Atsuko
Takahashi, Motohiro
Yokoi, Toshio
Tsuda, Yuko
Bryant, Sharon D.
Lazarus, Lawrence H.
Cyclization of dipeptidyl chloromethyl ketones gave 6-(4-aminobutyl)-3- carboxyethyl-5-methyl-2(1H)-pyrazinone, 3-(4-aminobutyl)-6-carboxyethyl-5- methyl-2(1H)-pyrazinone, and 3,6-bis(4-aminobutyl)-5-methyl-2(1H)-pyrazinone, which were inserted into the enkephalin sequence to give opioid mimetics. Thus, it was confirmed that a pyrazinone ring can be easily inserted into a peptide sequence in order to evaluate structural components required for biologically active peptides.
View MoreBeyond Pharmaceutical Co., Ltd
Contact:+86-571-8195-3185
Address:No. 13-1, Liansheng Road, Yuhang District
Nanjing Fayekong Chemcial Co.,Ltd(expird)
Contact:86-25-58813444
Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Contact:0086-29-89196322
Address:North of the Fifth Keji Road, Hi-Tech Industrial Zone, Xi'an City, Shaanxi Province, China
Shanghai Dianyang Industry Co.,ltd
Contact:+86 21 6492 4669
Address:Chejing RD, Songjiang District, Shanghai, China
Doi:10.1021/ja01045a023
(1969)Doi:10.1021/ja01292a018
(1936)Doi:10.1039/a900137i
(1999)Doi:10.1055/s-1982-30062
(1982)Doi:10.1021/ja990637m
(1999)Doi:10.1021/jm00316a056
(1967)
