Chemical and Pharmaceutical Bulletin p. 1193 - 1195 (1999)
Update date:2022-08-04
Topics:
Okada, Yoshio
Fukumizu, Atsuko
Takahashi, Motohiro
Yokoi, Toshio
Tsuda, Yuko
Bryant, Sharon D.
Lazarus, Lawrence H.
Cyclization of dipeptidyl chloromethyl ketones gave 6-(4-aminobutyl)-3- carboxyethyl-5-methyl-2(1H)-pyrazinone, 3-(4-aminobutyl)-6-carboxyethyl-5- methyl-2(1H)-pyrazinone, and 3,6-bis(4-aminobutyl)-5-methyl-2(1H)-pyrazinone, which were inserted into the enkephalin sequence to give opioid mimetics. Thus, it was confirmed that a pyrazinone ring can be easily inserted into a peptide sequence in order to evaluate structural components required for biologically active peptides.
View MoreLyrin Industrial Corporation Limited
Contact:86-731-82571800
Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Shijiazhuang Frontierchem Co., Ltd.
Contact:+86-311-89271196
Address:4-4-202 No.15 Biandian Street,Shijiazhuang
Hangzhou Zhenghan Biological Technology Co., Ltd.
Contact:86-571-88781753
Address:liangzhu yuhang hangzhou city
Shanghai united Scientific Co.,Ltd.
Contact:+86-21-53535353
Address:28F No.900 huaihai Road Shanghai China
Contact:+86 21 5017 5386
Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
Doi:10.1021/ja01045a023
(1969)Doi:10.1021/ja01292a018
(1936)Doi:10.1039/a900137i
(1999)Doi:10.1055/s-1982-30062
(1982)Doi:10.1021/ja990637m
(1999)Doi:10.1021/jm00316a056
(1967)
