New non-aromatic triazinic nucleosides : Synthesis and antiretroviral evaluation of β-ribosylamine nucleoside analogs

Article abstract of DOI:10.1080/07328319608002030

Various 5-alkyl-6-aza-5,6-dihydrouridines and 6-(β-D-ribopyranosyl)-5-alkyl-6-aza-5,6-dihydrouracils have been synthesized. A new regioselective method is described for coupling triazinic bases to the sugar unit. Different epimers were isolated. Antiretroviral activity against Visna virus was evaluated.

Full text of DOI:10.1080/07328319608002030

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Nucleosides and Nucleotides
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New Non-Aromatic Triazinic
Nucleosides: Synthesis and
Antiretroviral Evaluation of β-
Ribosylamine Nucleoside Analogs
Jean Depelley a , Robert Granet a , Mourad Kaouadji a , Pierre
Krausz a , Salomon Piekarski a , Sylvie Delebassée b & Claudine
Bosgiraud b
a Laboratoire de Chimie des Substances Naturelles, Faculté des
Sciences , 123 Av. Albert Thomas, 87060, Limoges Cedex, France
b UFR de Pharmacie, 2 Rue du Docteur Marcland , 87025,
Limoges Cedex, France
Published online: 15 Aug 2006.
To cite this article: Jean Depelley , Robert Granet , Mourad Kaouadji , Pierre Krausz ,
Salomon Piekarski , Sylvie Delebassée & Claudine Bosgiraud (1996) New Non-Aromatic Triazinic
Nucleosides: Synthesis and Antiretroviral Evaluation of β-Ribosylamine Nucleoside Analogs,
Nucleosides and Nucleotides, 15:5, 995-1008, DOI: 10.1080/07328319608002030
To link to this article: http://dx.doi.org/10.1080/07328319608002030
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