Bioorganic and Medicinal Chemistry Letters p. 1541 - 1546 (1999)
Update date:2022-08-04
Topics:
O'Connell, Celeste E.
Salvato, Kathleen A.
Meng, Zhaoyang
Littlefield, Bruce A.
Schwartz, C. Eric
The marine natural product hapalosin and 22 analogs, which incorporated systematic substituent deletions or variations, were prepared. These compounds were evaluated in a cell-based assay for both MDR-reversing activity and general cytotoxicity. Some substituent modifications resulted in lower cytotoxicities, but most structural changes were either detrimental to or did not seriously alter the MDR-reversing activity.
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