Bioorganic and Medicinal Chemistry Letters p. 1541 - 1546 (1999)
Update date:2022-08-04
Topics:
O'Connell, Celeste E.
Salvato, Kathleen A.
Meng, Zhaoyang
Littlefield, Bruce A.
Schwartz, C. Eric
The marine natural product hapalosin and 22 analogs, which incorporated systematic substituent deletions or variations, were prepared. These compounds were evaluated in a cell-based assay for both MDR-reversing activity and general cytotoxicity. Some substituent modifications resulted in lower cytotoxicities, but most structural changes were either detrimental to or did not seriously alter the MDR-reversing activity.
View MoreWuxi Pharma-Trading Import & Export Co.,Ltd.
Contact:+86-510-82304590 82716390
Address:Room 523,Youzu Alliance Building,No.88 Renmin Zhonglu,Wuxi,Jiangsu,China
Shandong Yaroma Perfumery Co., Ltd.
Contact:+86- 531- 88024598
Address:7-702 Caizhi Central, 59 Gong Ye South Road, Jinan City,250101, P. R. China
website:http://www.tcfinechem.com/
Contact:18681346930
Address:baifu town,whou district
Tianjin Dongchang Fine Chemical Industry Co., Ltd.
Contact:+86-22-29894595
Address:Economic Developing Zone, Ji County, Tianjin, China
Wuhan Jadechem International Trade Co.,Ltd.
website:http://www.jadechem-intl.com
Contact:+86-27-83527060
Address:Room 502,Building C11,Software new city No.8,Huacheng Avenue,East Lake High-tech development zone,Wuhan,Hubei,China
Doi:10.1055/s-1999-3091
(1999)Doi:10.1016/S0022-2860(96)09561-0
(1997)Doi:10.1021/jo00830a062
(1970)Doi:10.1021/ja402651q
(2013)Doi:10.1016/S0040-4039(99)00933-8
(1999)Doi:10.1016/j.tetlet.2006.01.121
(2006)
