Bioorganic and Medicinal Chemistry Letters p. 4837 - 4840 (2007)
Update date:2022-08-04
Topics:
Sutin, Lori
Andersson, Soeren
Bergquist, Lars
Castro, Victor M.
Danielsson, Eva
James, Stephen
Henriksson, Martin
Johansson, Lars
Kaiser, Christina
Flyren, Katarina
Williams, Meredith
2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.
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