An efficient synthesis of phenanthro-fused thiazoles by a non-phenolic oxidative coupling procedure of 4,5-diarylthiazoles

Article abstract of DOI:10.1016/S0040-4039(99)00982-X

A concise synthesis of the title compounds 6 is accomplished in high overall yield in a two step process starting from bromoketone 4. A thiazole ring formation and a non-phenolic oxidative coupling reaction using PIFA are features of the described synthesis. An exploration of the electronic requirements and the regioselectivity of the cyclization is also presented.