Enantiomerically pure 1,2-bis(isopropylmethylphosphino)benzene and its use in highly enantioselective Rh-catalyzed asymmetric hydrogenation

Article abstract of DOI:10.1016/S0040-4039(99)00856-4

A new P-chiral phosphine ligand with a 1,2-phenylene unit, (S,S)-1,2- bis(isoprophylmethylphosphino)benzene, has been synthesized from 1,2- bis(methylphosphino)benzene. Its rhodium complex is highly effective in asymmetric hydrogenation of dehydroamino ac