First total synthesis of tetrasubstituted tetrahydrofuran lignan, (-)- virgatusin

Article abstract of DOI:10.1016/S0040-4039(99)00848-5

The first asymmetric total synthesis of (-)-virgatusin, a new furanolignan, isolated from phyllanthus virgatus, was accomplished in a stereoselective manner by nucleophilic addition of organolithium reagent to the functionalized lactone elaborated from di