Structure-based design and synthesis of a novel class of Src SH2 inhibitors

DOI: 10.1016/S0960-894X(99)00388-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2353 - 2358 (1999)

Update date:2022-08-03

Topics:

Authors:

Buchanan, John L.

Bohacek, Regine S.

Luke, George P.

Hatada, Marcos

Lu, Xiaode

Dalgarno, David C.

Narula, Surinder S.

Yuan, Ruth

Holt, Dennis A.

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Article abstract of DOI:10.1016/S0960-894X(99)00388-1

The structure-based design and synthesis of a novel class of 2,4- disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.

Full text of DOI:10.1016/S0960-894X(99)00388-1

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