The copper mediated Barbier reactions of α,β-unsaturated ketones: Regioselective conjugate and 1,2-addition

Article abstract of DOI:10.1080/00397919908085932

The one-pot reaction of isophorone and other α,β-unsaturated ketones with alkyl and aryl halides in the presence of magnesium and a copper salt ('Barbier' conditions) leads to the regiospecific formation of 1,4-addition products; the use of lithium leads to regioselective 1,2-addition.

Full text of DOI:10.1080/00397919908085932

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The Copper Mediated Barbier
Reactions of α,β-Unsaturated
Ketones: Regioselective Conjugate
and 1,2-Addition
Declan P. Costello a & Niall W. A. Geraghty a
a Chemistry Department , National University of Ireland ,
Galway, Ireland
Published online: 17 Sep 2007.
To cite this article: Declan P. Costello & Niall W. A. Geraghty (1999) The Copper Mediated
Barbier Reactions of α,β-Unsaturated Ketones: Regioselective Conjugate and 1,2-Addition,
Synthetic Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 29:18, 3083-3096, DOI: 10.1080/00397919908085932
To link to this article: http://dx.doi.org/10.1080/00397919908085932
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