Bioorganic and Medicinal Chemistry Letters p. 2013 - 2018 (1999)
Update date:2022-09-26
Topics:
Buijsman, Rogier C.
Basten, Jan E. M.
Van Dinther, Theo G.
Van der Marel, Gijsbert A.
Van Boeckel, Constant A. A.
Van Boom, Jacques H.
The synthesis of a novel antithrombotic consisting of a heparin pentasaccharide conjugated to the active site inhibitor N-(2- naphtalenesulfonyl)-glycyl-(D)-4-aminophenyl-alanyl-piperidine (NAPAP) (i.e. compound I) is reported. This conjugate shows a unique pharmacological profile both in vitro and in vivo having direct anti-thrombin and ATIII- mediated anti-Xa activity. Furthermore, conjugate I has a prolonged in vivo half-life compared to NAPAP (1.5 h vs 9 min.).
View MoreGolden Union Agrochemical Import and Export Co., Ltd.
Contact:86-755-23910527
Address:Room 1106, Tower 3A, Excellence Century Center, Futian District, Shenzhen, China
website:https://www.yacoo.com.cn/en/
Contact:86-512-87182055
Address:No.112 Xinqing Rd, Suzhou Industrial Park, China, 215125, China
Contact:86-371-63655023
Address:No.85,jinshui road,zhengzhou,China
Shanghai Sungo Technology Chemical Co., Ltd
Contact:0086-21-51385579
Address:Room2010, F/20, Tonghua Plaza, NO 345 Jinxiang Road, Jinqiao Export Processing Zone, Shanghai, 201206 P.R.CHINA
NingBO Hong Xiang Biochem.Co.Ltd
website:http://www.hxbiochem.com
Contact:0574-66003444
Address:Ning Bo Bei Lun
Doi:10.1021/ja00506a029
(1979)Doi:10.1016/S0040-4039(97)01496-2
(1997)Doi:10.1002/adsc.201900264
(2019)Doi:10.1021/ja01014a047
(1968)Doi:10.1055/s-1999-2902
(1999)Doi:10.1016/j.bmcl.2007.03.066
(2007)
