Bioorganic and Medicinal Chemistry Letters p. 2013 - 2018 (1999)
Update date:2022-09-26
Topics:
Buijsman, Rogier C.
Basten, Jan E. M.
Van Dinther, Theo G.
Van der Marel, Gijsbert A.
Van Boeckel, Constant A. A.
Van Boom, Jacques H.
The synthesis of a novel antithrombotic consisting of a heparin pentasaccharide conjugated to the active site inhibitor N-(2- naphtalenesulfonyl)-glycyl-(D)-4-aminophenyl-alanyl-piperidine (NAPAP) (i.e. compound I) is reported. This conjugate shows a unique pharmacological profile both in vitro and in vivo having direct anti-thrombin and ATIII- mediated anti-Xa activity. Furthermore, conjugate I has a prolonged in vivo half-life compared to NAPAP (1.5 h vs 9 min.).
View MoreChangsha Huajing Powdery Material Technological Co., Ltd.
Contact:86-731-88879686
Address:Building 2, West Garden, Main Campus of Central South University, Changsha, Hunan Province, China
Nanjing Capatue Chemical Co., Ltd
Contact:+86-25-86371192 +86-025-85720158
Address:No.20 Jiangjun Avenue, Jiangning Economic & Technical Development Zone
Contact:+86-570-4336358
Address:No.87 Building,Tianqian,Sidu Town
Wuxi D-Stone International Co., Ltd.
Contact:+86-510-82740567
Address:21F Hengtong Int'l Centre, 215Zhongshan Road, Wuxi, Jiangsu,China
website:http://www.apeptides.com/en/
Contact:+86-21-60871011
Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai
Doi:10.1021/ja00506a029
(1979)Doi:10.1016/S0040-4039(97)01496-2
(1997)Doi:10.1002/adsc.201900264
(2019)Doi:10.1021/ja01014a047
(1968)Doi:10.1055/s-1999-2902
(1999)Doi:10.1016/j.bmcl.2007.03.066
(2007)
