Bioorganic and Medicinal Chemistry Letters p. 2013 - 2018 (1999)
Update date:2022-09-26
Topics:
Buijsman, Rogier C.
Basten, Jan E. M.
Van Dinther, Theo G.
Van der Marel, Gijsbert A.
Van Boeckel, Constant A. A.
Van Boom, Jacques H.
The synthesis of a novel antithrombotic consisting of a heparin pentasaccharide conjugated to the active site inhibitor N-(2- naphtalenesulfonyl)-glycyl-(D)-4-aminophenyl-alanyl-piperidine (NAPAP) (i.e. compound I) is reported. This conjugate shows a unique pharmacological profile both in vitro and in vivo having direct anti-thrombin and ATIII- mediated anti-Xa activity. Furthermore, conjugate I has a prolonged in vivo half-life compared to NAPAP (1.5 h vs 9 min.).
View MoreZibo Ocean International Trade Co.,Ltd(expird)
Contact:+86 533 5160706
Address:1117, Hongtai Bld., Songling rd, Zichuan,Zibo,Shandong,China
Shanghai Yanchu chemicals Co., Ltd
website:http://www.yanchuchem.com
Contact:0086 18601657701
Address:Room 1292, Building NO. 2, Lane 65, Huandong 1st Rd, Fengjing Town, Jinshan Distriction, shanghai
YingYing Pharmaceutical Co.,Ltd
Contact:86-18854126208
Address:55#, yingxiongshan road
Suzhou SuKaiLu Chemical Technology Co., Ltd.
Contact:+86-512-62766020
Address:Floor 4, Building 1, Xinyi Pharmaceutical Valley Wisdom Industrial Park, 415 Changyang Street, Suzhou Industrial Park, Jiangsu Province
website:http://www.antimex.com
Contact:0086-21-50563169
Address:Room1027,No.Jinyu Road,Pudong
Doi:10.1021/ja00506a029
(1979)Doi:10.1016/S0040-4039(97)01496-2
(1997)Doi:10.1002/adsc.201900264
(2019)Doi:10.1021/ja01014a047
(1968)Doi:10.1055/s-1999-2902
(1999)Doi:10.1016/j.bmcl.2007.03.066
(2007)
