Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists

DOI: 10.1016/j.bmcl.2007.03.066

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2987 - 2991 (2007)

Update date:2022-09-26

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Authors:

Kulkarni, Santosh S.

Newman, Amy Hauck

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Article abstract of DOI:10.1016/j.bmcl.2007.03.066

Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5.

Full text of DOI:10.1016/j.bmcl.2007.03.066

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