Bioorganic and Medicinal Chemistry Letters p. 2235 - 2239 (2001)
Update date:2022-08-05
Topics:
Ludovici, Donald W.
De Corte, Bart L.
Kukla, Michael J.
Ye, Hong
Ho, Chih Y.
Lichtenstein, Mark A.
Kavash, Robert W.
Andries, Koen
De Bethune, Marie-Pierre
Azijn, Hilde
Pauwels, Rudi
Lewi, Paul J.
Heeres, Jan
Koymans, Lucien M.H.
De Jonge, Marc R.
Van Aken, Koen J.A.
Daeyaert, Frederik F.D.
Das, Kalyan
Arnold, Edward
Janssen, Paul A.J.
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.
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