Bioorganic and Medicinal Chemistry Letters p. 2329 - 2334 (1999)
Update date:2022-08-03
Topics:
Receveur, Jean-Marie
Bryans, Justin S.
Field, Mark J.
Singh, Lakhbir
Horwell, David C.
A series of conformationally restricted Gabapentin analogues has been synthesised. The pyrrolidine analogue (R)-2-Aza-spiro[4.5]decane-4-carboxylic acid hydrochloride (3a) had an IC50 of 120nM, similar to that of Gabapentin (IC50 = 140nM), at the Gabapentin binding site on the α2δ subunit of a calcium channel. Compound (3a) also reversed carrageenan induced hyperalgesia in rats.
View MoreShanghai Potomer International Trade CO., LTD
Contact:+86-21-61397128
Address:Room 304,No.505 ,Caoyang Road.Shanghai,China
Shanghai Dano Pharmaceutical Co.,Ld.(expird)
Contact:+86-592-6266840
Address:Building 1 Room 512, 720 Cailun Rd, Zhangjiang High-Tech Park, Shanghai 201203, China
taicang liyuan chemical co,.ltd
website:http://www.tcliyuanchem.com/productse.php
Contact:86-512-53539583
Address:Room 804,Huaxu Building,No.95,Renmin South Road,Taicang city,Jiangsu Province,China
HAINAN JINYING IMPORT AND EXPORT CO. LTD
Contact:+86-898-32875423
Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Contact:86-21-57725962
Address:shanghai
Doi:10.1021/jo01110a002
(1956)Doi:10.1515/znb-1999-0816
(1999)Doi:10.1246/bcsj.42.3008
(1969)Doi:10.1246/bcsj.67.895
(1994)Doi:10.1139/v69-008
(1969)Doi:10.1016/j.tetlet.2006.05.027
(2006)